Oral Cancer: A Medical Insight into Mouth Tumors

Mouth cancer

What is mouth cancer? A Mayo Clinic expert explains

Learn more about mouth cancer, also called oral cancer, from oncologist Katharine Price, M.D.

Mouth cancer is a growth of cells that starts in the mouth. Mouth cancer can happen in any of the parts that make up the mouth.

Mouth cancer can occur on the:

• Lips.
• Gums.
• Tongue.
• Inner lining of the cheeks.
• Roof of the mouth.
• Floor of the mouth.

The mouth also is called the oral cavity. Cancer that happens in the mouth is sometimes called oral cancer or oral cavity cancer.Mouth cancer is one of several cancers that are considered to be types of head and neck cancer. Mouth cancer and other head and neck cancers often have similar treatments.

Symptoms

• Lip cancer
• Lip cancer
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• Mouth cancer
• Mouth cancer — red sore
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Signs and symptoms of mouth cancer may include:

• A lip or mouth sore that won't heal.
• A white or reddish patch on the inside of the mouth.
• Loose teeth.
• A growth or lump inside the mouth.
• Mouth pain.
• Ear pain.
• Difficult or painful swallowing.

Causes

It's not always clear what causes mouth cancer. This cancer starts as a growth of cells in the mouth. It most often starts in cells called squamous cells. These are flat, thin cells that line the lips and the inside of the mouth. Most oral cancers are squamous cell carcinomas. Mouth cancer happens when cells on the lips or in the mouth develop changes in their DNA. A cell's DNA holds the instructions that tell the cell what to do. In healthy cells, the DNA tells the cells to grow and multiply at a set rate. The DNA also tells the cells to die at a set time.

In cancer cells, the DNA changes give different instructions. The changes tell the cancer cells to grow and multiply quickly. Cancer cells can keep living when healthy cells would die. This causes too many cells.

The cancer cells might form a mass called a tumor. The tumor can grow to invade and destroy healthy body tissue. In time, the cancer cells can break away and spread to ther parts of the body. When cancer spreads, it's called metastatic cancer.

Risk factors

Factors that can increase the risk of mouth cancer include:

Using tobacco

All forms of tobacco increase the risk of mouth cancer. This includes cigarettes, cigars, pipes, chewing tobacco and snuff.

Drinking alcohol

Frequent and heavy drinking increases the risk of mouth cancer. Using alcohol and tobacco together increases the risk even more.

Excessive sun exposure to the lips

Ultraviolet light from the sun and tanning lamps increases the risk of lip cancer.

Being exposed to human papillomavirus

Human papillomavirus, also called HPV, is a common virus that's passed through sexual contact. For most people, it causes no problems and goes away on its own. For others, it causes changes in the cells that can lead to many types of cancer, including mouth cancer.

A weakened immune system

If the body's germ-fighting immune system is weakened by medicines or illness, there might be a higher risk of mouth cancer. People with a weakened immune system include those taking medicines to control the immune system, such as after an organ transplant. Certain medical conditions, such as infection with HIV, also can weaken the immune system.

Prevention

There's no proven way to prevent mouth cancer. However, you may reduce your risk of mouth cancer if you:

Don't use tobacco

If you don't use tobacco, don't start. If you currently use tobacco of any kind, talk with your healthcare team about strategies to help you quit.

Limit alcohol intake

If you choose to drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women and up to two drinks a day for men.

Avoid excessive sun exposure to your lips

Protect the skin on your lips from the sun by staying in the shade when possible. Wear a broad-brimmed hat that shades your entire face, including your mouth. Apply a sunscreen lip product for sun protection.

Consider the HPV vaccine

Receiving a vaccination to prevent HPV infection may reduce your risk of HPV-related cancers, such as mouth cancer. Ask your healthcare team whether the HPV vaccine is appropriate for you.

Have regular health and dental exams

During your appointments, your dentist, doctor or other member of your healthcare team can check your mouth for signs of cancer.